Assembling defined DNA nanostructures with anticancer drugs: a metformin/DNA complex nanoplatform with a synergistic antitumor effect for KRAS-mutated lung cancer therapy
نویسندگان
چکیده
Abstract Herein, a strategy is proposed to simultaneously deliver the small-molecule drug metformin and siRNA with self-assembled DNA nanostructures. The biomedical application of nanostructures highly promising but still in its infancy. as delivery vehicles are conventionally synthesized magnesium-containing buffer. We propose using an anticancer assemble them for synergistic therapy. cargo induces self-assembly into well-defined, uniform nanostructures, producing drug–DNA nanocomplex multiple functionalities cancer Both tile-based origami structures can be assembled metformin. as-prepared metformin/DNA showed high structural thermal stability enzymatic resistance physiological settings. KRAS G12C exerted strong, antitumor effect against KRAS-mutated non-small cell lung (NSCLC) both vitro vivo by suppressing RAS/AKT/mTOR AMPK/AKT/mTOR signaling pathways. current study suggests that assembly complex nanomaterials carefully chosen small molecules key endowing new subsequently expanding their applications multidisciplinary research fields.
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ژورنال
عنوان ژورنال: Npg Asia Materials
سال: 2022
ISSN: ['1884-4049', '1884-4057']
DOI: https://doi.org/10.1038/s41427-022-00427-y